Moving RNA moves RNA forward

RNA Isolation (Small RNA Extraction). Fatemeh Mehrpooyan*

Enhancement of RNA Interference Effect in P19 EC Cells by an RNA-dependent RNA Polymerase

Background: RNA interference (RNAi) is a phenomenon uses double-stranded RNA (dsRNA) to specifically inhibit gene expression. The non-specific silencing caused by interferon response to dsRNA in mammalian cells limits the potential of utilizing RNAi to study gene function. Duplexes of 21-nucleotide short interfering dsRNA (siRNA) inhibit gene expression by RNAi. In some organisms, siRNA can als...

Blocking cancer with RNA interference moves toward the clinic.

The discovery of RNA interference (RNAi), the endogenous regulatory system that employs small doublestranded RNA molecules to silence gene expression, has generated enthusiasm for using small interfering RNA – based molecules (siRNA) to treat a variety of diseases. It didn’t take long for investigators to dream up several strategies for siRNA to target cancer. And recent studies offer tantalizi...

RNA nanotechnology breakthrough for targeted release of RNA-based drugs using cell-based aptamers

Nucleic acids play different roles besides storing information and proteins coding. For example, single-stranded nucleic acids can fold into complicated structures with capability of molecular detection, catalyzing bioreactions and therapy. The development of RNA-based therapies has been rapidly progressed in the recent years. RNA aptamers are biomolecules with a size of 10 to 50 nm that can be...

RNA isolation (Total RNA Extraction from High Polysaccharide Plants). Fatemeh Mehrpooyan*